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DC Field | Value | Language |
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dc.contributor.author | Mehnaz, Samina | - |
dc.contributor.author | Chaudhury, Chaity | - |
dc.contributor.author | Kim, Joghan | - |
dc.contributor.author | Wani, Manzoor A. | - |
dc.contributor.author | M Oberyszyn, Tatiana | - |
dc.contributor.author | Bronson, C L | - |
dc.contributor.author | Mohanty, Sudharsi | - |
dc.contributor.author | L Hayton, William | - |
dc.contributor.author | Robinson, John M | - |
dc.contributor.author | Anderson, Clark L | - |
dc.date.accessioned | 2021-02-03T08:20:50Z | - |
dc.date.available | 2021-02-03T08:20:50Z | - |
dc.date.issued | 2006-12-01 | - |
dc.identifier.citation | Chaudhury C, Kim J, Mehnaz S, Wani MA, Oberyszyn TM, Bronson CL, Mohanty S, Hayton WL, Robinson JM, Anderson CL. Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation. J Nutr. 2006 Dec;136(12):2993-8. doi: 10.1093/jn/136.12.2993. PMID: 17116709. | en_US |
dc.identifier.other | 10.1093/jn/136.12.2993. | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/1032 | - |
dc.description | Publication types Research Support, N.I.H., Extramural | en_US |
dc.description.abstract | HFE, a major histocompatibility complex class I-related protein, is implicated in the iron overload disease, hereditary hemochromatosis. Whereas patients with hereditary hemochromatosis have low serum transferrin levels, little is known about transferrin turnover in HFE deficiency states. We injected mice intravenously with radioiodinated transferrin and compared plasma transferrin decay and steady-state endogenous transferrin concentration in the plasma between HFE-deficient and wild-type C57BL/6 mouse strains. HFE-deficient mice degraded transferrin faster than normal (P < 0.001) and had lower plasma transferrin concentrations (P < 0.001). Both HFE-deficient and wild-type mice were then fed diets with 3 different iron concentrations that we designated deficient (2-5 mg/kg of iron), control (0.2 g/kg), and overload (20 g/kg) for 6 wk immediately after weaning to create a range of serum iron concentrations and resultant transferrin saturations ranging from 16 to 78%. We found an inverse correlation between transferrin saturation and transferrin half-life (P < 0.0001, r = -0.839) for both HFE-deficient and wild-type mice, which suggests that HFE does not have a direct effect on transferrin catabolism; rather, HFE may influence transferrin half-life indirectly through its effect on transferrin saturation, which in turn enhances transferrin decay in HFE-deficient mice. | en_US |
dc.description.sponsorship | AI57530/AI/NIAID NIH HHS/United States CA88053/CA/NCI NIH HHS/United States HD38764/HD/NICHD NIH HHS/United States | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Journal of Nutrition, PubMed.gov, National Library of Medicine, National Center for Biotechnology Information | en_US |
dc.relation.ispartofseries | 2006 Dec;136(12):2993-8.;PMID: 17116709 | - |
dc.subject | Animal Feed | en_US |
dc.subject | Mice | en_US |
dc.subject | Hemochromatosis Protein | en_US |
dc.subject | Histocompatibility Antigens Class I | en_US |
dc.subject | Immunoglobulin A / metabolism | en_US |
dc.subject | Kinetics | en_US |
dc.subject | Membrane Proteins / deficiency* | en_US |
dc.subject | Male | en_US |
dc.subject | Mice, Inbred C57BL | en_US |
dc.subject | Mice Knockout | en_US |
dc.subject | Proteinuria | en_US |
dc.subject | Reference values | en_US |
dc.subject | Transferrin / metabolism* | en_US |
dc.subject | Transferrin / pharmacokinetics | en_US |
dc.title | Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Life Sciences |
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transferrin.journal of nutrition.pdf | 159.22 kB | Adobe PDF | View/Open |
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