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http://digitalrepository.fccollege.edu.pk/handle/123456789/1248
Title: | Evaluation of methanolic extract of Phragmites karka on carbon tetrachloride-induced liver fibrosis in rat |
Authors: | Rehman, Atta Ur Liaquat, Manal Asghar, Rabia Syed, Nawazish-i-Husain |
Keywords: | Evaluation liver fibrosis rats CCL4 |
Issue Date: | 2017 |
Publisher: | Bangladesh journal of pharmacology |
Citation: | Rehman AU, Liaquat M, Asghar R, Syed N. Evaluation of methanolic extract of Phragmites karka on carbon tetrachloride-induced liver fibrosis in rat. Bangladesh J Pharmacol. 2017; 12: 276-81. |
Series/Report no.: | Bangladesh J Pharmacol 2017; 12: 276-281; |
Abstract: | Phragmites karka has been reported for its anti-inflammatory and analgesic activities. Here, extracts of leaf and rhizome of the plant were individually investigated in CCl4-induced hepatofibrosis in male Wistar rats by adminis tering CCl4 intraperitoneally biweekly for 6 weeks. Afterwards the animals were investigated for liver fibrosis at biochemical, molecular and histological levels, and it showed a profound increase (p<0.001) in elevation of serum levels of transaminases, DŽ-glutamyl transpeptidase, mRNA expression of ǂ smooth muscle actin, collagen and transforming growth factor beta (TGFǃ), and extracellular matrix deposition and perilobular necrosis. Both extracts markedly (p<0.001) decreased the elevated levels of these markers. Histopathological investigations also substantiated the above results by exhibiting a decreased in extracellular matrix deposition in post-treatment animals. In conclusion, both extracts had substantially modified the bioche mical and molecular markers of liver fibrosis, in addition to histological improvement in architecture of liver |
Description: | https://www.banglajol.info/index.php/BJP/article/view/32127 |
URI: | http://localhost:8080/xmlui/handle/123456789/1248 |
ISSN: | ISSN: 1991-0088 |
Appears in Collections: | Pharmacy Department |
Files in This Item:
File | Description | Size | Format | |
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20160701 BJP Evaluation_of_methanolic_extract_of_Phragmites_kar ok.pdf | 1.18 MB | Adobe PDF | View/Open |
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