Neurotoxicity of ZnO nanoparticles and associated motor function defcits in mice

Abstract

Nano-sized zinc is extensively used by various industries and exposure of humans to these nanoparticles is increasing by the day. Mounting evidence suggests that health hazards are induced by metallic nanoparticles. However, at present, there is insufcient information concerning the impairment of motor functions due to exposure to metallic nanoparticles, particularly zinc oxide (ZnO) nanoparticles. The present study evaluates the toxic efects of ZnO nanoparticles in Swiss albino mice. Motor functions impairments were monitored using beam balance, and pole and footprint tests. Results showed that ZnO nanoparticles cause defcits in normal motor functions. Histopathological investigations revealed signifcantly (p<0.01) increased motor cortex nuclear size probably resulting from neuroinfammation/neuronal damage. Overall, it is concluded that ZnO nanoparticles induce neurotoxicity resulting in motor function impairments.