Anti-inflammatory and selective COX-2 inhibitory activities of metal complexes of Schiff bases derived from aldoses

Abstract

Mn(II)-, Fe(II)-, Co(II)-, Ni(II)-, and Zn(II)- Schiff base complexes containing anthranilic acid and aldoses as part of the base were prepared and characterized by microanalytical, thermogravimetric, and spectroscopic data. The complexes were found to be four-coordinate, anhydrous, and ML2 type. The spectral and magnetic data indicate a tetrahedral geometry for Mn(II) and Fe(II) complexes, and a planar geometry for Co(II), Ni(II), and Zn(II) complexes. Mn(II) and Zn(II) complexes showed a significant anti-inflammatory activity against kaolin-paw edema. All the complexes exhibited selective inhibition of COX-2 in two different cell models