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dc.contributor.authorSaeed Iqbal, Mohammad-
dc.contributor.authorAkmal, Muhammad-
dc.contributor.authorChaudhry, JA-
dc.date.accessioned2024-05-28T06:57:52Z-
dc.date.available2024-05-28T06:57:52Z-
dc.date.issued2000-01-
dc.identifier.citationAkmal, Muhammad & Chaudhry, JA & Iqbal, Mohammad. (2000). The HPLC analysis of process materials of semi-synthetic penicillins. Chromatographia. 51. 756-758. 10.1007/BF02505416.en_US
dc.identifier.otherDOI:10.1007/BF02505416-
dc.identifier.urihttp://202.142.177.21/handle/123456789/2272-
dc.descriptionA method for simultaneous determination of D(-)-phydroxyphenylglycine, D(-)-~-phenylglycine and 6-aminopenicillanic acid in in-process materials and effluents produced in the manufacturing of amoxycillin, ampicillin and cloxacillin sodium has been developed and validated. The method is simple, rapid and does not require special sample pre-treatment. The mobile phase does not include any special agent such as ion-pairing and the analysis can be performed at room temperature. The linearity of the response and precision are good. The method can be applied for the routine monitoring of the analytes in process streams and effluents with good reliability. The method is being successfully used for such determinations for about two years at Pharmagen Beximco Ltd. Lahore for the manufacture of amoxycillin, ampicillin and cloxacillin sodium.en_US
dc.description.abstractAn HPLC method for the determination of D(-)-p-hydroxyphenylglycine, D(-)-~-phenylglycine and 6-aminopenicillanic acid has been developed using a 5 #m Hypersil Spherisorb ODS 1 column (250 x 4.6mm). These analytes were separated in a single run under isocratic conditions. Various chromatographic parameters including linearity, precision and accuracy have been evaluated. The method was found to be suitable for the analysis of process materials and effluents associated with the manufacture of amoxycillin, ampicillin and cloxacillin sodium. The run time is less than five minutes.en_US
dc.language.isoen_USen_US
dc.publisherresearchgate.neten_US
dc.subjectColumn liquid chromatography Semi-synthetic penicillins Process effluentsen_US
dc.titleThe HPLC Analysis of Process Materials of Semi-synthetic Penicillinsen_US
dc.typeArticleen_US
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