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http://digitalrepository.fccollege.edu.pk/handle/123456789/475
Title: | A Spectroscopic Study of Interaction of Auricyanide with N-Acetylcysteine |
Authors: | Iqbal, Mohammad S. Kazimi, Syed Shaw, Frank |
Keywords: | Chemistry |
Issue Date: | 14-Sep-2017 |
Publisher: | Cross Mark |
Abstract: | Interaction of auricyanide, an important metabolite of anti-arthritic gold-based drug auranofin, was studied in vitro with a pharmacologically active ligand Nacetylcysteine with a view to understand reactivity of gold in vivo. Formation of reduction product aurocyanide occurred through mono- and di-N-acetylcysteine-substituted intermediates. The product and intermediates were identified and monitored spectrophotometrically and by electrospray ionization mass spectrometry. This study suggests successive substitution with N-acetylcysteine through trans effect. At equimolar concentrations of auricyanide and N-acetylcysteine, only mono-substituted mixed-ligand complex was formed. Substitution of the data obtained to various kinetic models suggested that the reaction orders are 0.6 in terms of Nacetylcysteine, 1.5 in terms of auricyanide, and 2 overall. The intermediates detected in this work may help to synthesize more effective and less toxic gold drugs. |
URI: | http://localhost:8080/xmlui/handle/123456789/475 |
Appears in Collections: | Chemistry Department |
Files in This Item:
File | Description | Size | Format | |
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BTER2018.pdf | 883.8 kB | Adobe PDF | View/Open |
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