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http://digitalrepository.fccollege.edu.pk/handle/123456789/480
Title: | In Situ Synthesis, Encapsulation in Arabinoxylan and Release Kinetics of Microcrystalline Copper(II)-Aspirinate |
Authors: | Iqbal, Mohammad S. Iram, Fozia Ahmed, Riaz Khan, Abdul H. Sher, Muhammad |
Keywords: | Chemistry |
Issue Date: | 17-Apr-2018 |
Publisher: | Latin American Journal of Pharmacy |
Abstract: | Microcrystalline copper(II)-aspirinate was synthesized in situ by allowing copper(II) acetate monohydrate and aspirin to react in pre-swollen arabinoxylan (AX) from ispaghula (Plantago ovata) husk in aqueous medium. The method resulted in formation of microcrystalline (< 40 mm) copper(II)-aspirinate dispersed in AX matrix. The product was characterized by microscopic FT-IR spectroscopy, pXRD, scanning electron microscopy and atomic force microscopy. The AX-encapsulated copper(II)-aspirinate exhibited a smooth release profile of aspirin over 8 h following Korsmeyer-Peppas model for swellable polymer films in alkaline medium. The release was of Fickian type with n = 0.5. The release rate appeared to follow the order: alkaline pH > distilled water > acidic pH suggesting the pH-dependent release from AX. These profiles were highly sustained as compared with those of the naked drug. |
URI: | http://localhost:8080/xmlui/handle/123456789/480 |
Appears in Collections: | Chemistry Department |
Files in This Item:
File | Description | Size | Format | |
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LAJP2018.pdf | 855.21 kB | Adobe PDF | View/Open |
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