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http://digitalrepository.fccollege.edu.pk/handle/123456789/543| Title: | ImmunosuppressiveEffectsofNaturala,b-UnsaturatedCarbonyl-BasedCompounds,andTheirAnalogsandDerivatives,onImmuneCells:AReview |
| Authors: | Arshad, Laiba Jantan, Ibrahim Haque, Md. Areeful Bukhari, Syed Nasir Abbas |
| Keywords: | Pharmacy |
| Issue Date: | 30-Jan-2017 |
| Publisher: | Frontiers in Pharmacology |
| Abstract: | Theimmunesystemiscomplexandpervasiveasitfunctionstopreventorlimitinfectionsinthehumanbody.Inahealthyorganism,theimmunesystemandtheredoxbalanceofimmunecellsmaintainhomeostasiswithinthebody.Thefailuretomaintainthebalancemayleadtoimpairedimmuneresponseandeitheroveractivityorabnormallylowactivityoftheimmunecellsresultinginautoimmuneorimmunedeficiencydiseases.Compoundscontaininga,b-unsaturatedcarbonyl-basedmoietiesareoftenreactive.Thereactivityofthesegroupsisresponsiblefortheirdiversepharmacologicalactivities,andthemostimportantandwidelystudiedincludethenaturalcompoundscurcumin,chalcone,andzerumbone.Numerousstudieshaverevealedthemainlyimmunosuppressiveandanti-inflammatoryactivitiesoftheaforesaidcompounds.Thisreviewhighlightsthespecificimmunosuppressiveeffectsofthesenaturala,b-unsaturatedcarbonyl-basedcompounds,andtheiranalogsandderivativesondifferenttypesofimmunecellsoftheinnate(granulocytes,monocytes,macrophages,anddendriticcells)andadaptive(Tcells,Bcells,andnaturalkillercells)immunesystems.Theinhibitoryeffectsofthesecompoundshavebeencomprehensivelystudiedonneutrophils,monocytesandmacrophagesbuttheireffectsonTcells,Bcells,naturalkillercells,anddendriticcellshavenotbeenwellinvestigated.Itisofparamountimportancetocontinuegeneratingexperimentaldataonthemechanismsofactionofa,b-unsaturatedcarbonyl-basedcompoundsonimmunecellstoprovideusefulinformationforensuingresearchtodiscovernewimmunomodulatingagents. |
| URI: | http://localhost:8080/xmlui/handle/123456789/543 |
| Appears in Collections: | Pharmacy Department |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| frontiers in pharmacolog alpha beta.pdf | 1.4 MB | Adobe PDF | View/Open |
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